Gene Candidates

 

 

 

 

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5-hydroxytryptamine (serotonin) receptor 1A (5HT1A)
 
Variant Association Phenotype Sample Information Author
C1019G Allelic: ns Genotypic: ns Suicide Ethnicity: Slovenian

Videtic, 2009
Cases: Suicide Completers n=323, mean age: 48.3 ± 18.3 , Sex ratio: 2.9

Controls: n=190, mean age: 49 ± 17.8, Sex ratio: 1.9

Pro16leu

 

Allelic: ns
Genotypic: ns

Suicide

Ethnicity: Japanese

 Ohtani, 2004
Cases: suicide completers (F:39,mean age ± SD, 63.5±16.2; M: 95,mean age ± SD, 55.4±16.1)
Healthy controls: F:154,mean age ± SD: 48.9±15.9; M: 171, mean age ± SD: 48.1±14.8

 

C1019G

 

 

 Allelic: ns
Genotypic: ns

Suicide &

Suicide attempts

Psychiatric cases: n:696 (F:66%,mean age ± SD: 38±13) , including 214 suicide attempters Ethnicity: Caucasian/ African-Hispanic/ Asian/other: 479/113/86/10/8

Huang, 2004

 

Postmortem cases: 85 suicides (F:27%; mean age ± SD, 43.3±20) Ethnicity: Caucasian/ African-Hispanic/ Asian/ other: 61/9/12/3
156 nonsuicidal controls (F:22%; mean age ± SD, 43.0±17) Ethnicity: Caucasian/ African-Hispanic/Asian/ other: 86/46/20/4
Healthy volunteers: n:107 (F:45%; mean age ± SD, 39±15) Ethnicity: Caucasian/African-Hispanic/ Asian/other: 74/12/14/6/1

Notes: association seen for schizophrenia, substance abuse, panic attack but not for major depression or bipolar disorder: 5HT1 receptor binding not associated with genotype
C1019G

Allelic: +,G, p<.001

Genotypic:+, GG, p=.002

 Suicide

Cases: mood-disordered patients (F: 76, M:53; mean age: 43±11) Healthy volunteers (F:79, M:55; mean age: 36±12) Ethnicity: mostly Caucasian, Ontario

 Lemonde 2003
Cases: suicide completers (F:4, M:98; mean age: 32±9) Healthy controls (M:116; mean age: 34±11) Ethnicity: French Canadian
Notes: C1019 asociated with major depression
Pro16Leu Allelic: ns
Genotypic:ns		 Suicide Ethnicity: Japanese Nishiguchi, 2002
Cases: suicide completers: F:50, M:113; mean age ± SD, 47.9±17.6
Healthy controls: F:50, M:113; mean age ± SD, 44.7±14.9
Gly272Asp Allelic: ns
Genotypic: ns

rs1423691
rs878567
rs6295

Genotypic: ns Haplotypic: ns

Suicide attempts &

Suicide

Ethnicity: German,Italian

Serretti, 2007

Cases: 1a. German suicide attempters: n:167(F :109), mean age: 39.89±13.89, 101 impulsive, 60 violent 1b. Suicides: n:92 (F:39)
2a.Italian mood disordered patients [n: 463 subjects (F:308; 49.50±13.52), including  152 suicide attempters; mean age 50.00±13.02 and 311 nonsuicide patients, mean age49.25±13.77]
Controls: 3a. German: 312 (F:174;  mean age 45.01±14.92 years (range 19–79); 3b. Italian: 131 Italian healthy volunteers (F:47,M:84, aged 48.01±13.82)

Notes: only rs6295 analyzed in the Italian sample

Notes: += positive,significant; -=negative,significant; ns= nonsignificant; F=females; M=males

5-hydroxytryptamine (serotonin) receptor 1B (5HT1B)
Variant Association Phenotype Sample Information Author

C861G

G371T

 Allelic: ns Suicidal behaviour severity
Cases: 336 (F:62%) bipolar patients from 305 nuclear families (mean age: 35.36± 10.37), including 267 patients with histories of suicide ideas or attempts

De Luca, 2007
Notes: suicidality assessed quantitatively and coded as follows: 0 = absence of suicide/death thoughts, 1 = thoughts of death, 2 = suicide ideation, 3 = suicide plan, 4 = suicide attempt; marginal association of TH and severe suicidal behaviour
A161T

Allelic:+,T,p=.05 Genotypic:-,TT, p=.08

 Suicide Ethnicity: French Canadian Zouk, 2007

T261G

C129T

G861C

A1180G

Allelic: ns

Genotypic: ns

 Cases: 338 suicide completers (F:64, mean age: 38 ± 11.04)
Controls: 358 (F:75, mean age: 36.08 ± 15.71) nonsuicidal/nonpsychiatric controls
Notes: 161T allele homozygotes had higher aggression scores;
  Haplotypic: ns
A161T Allelic: ns
Genotypic: ns		 Suicide attempts Ethnicity: Han Chinese

Tsai, 2004
Cases: 160 psychiatric outpatients with major depressive disorder (M:71, 15 suicide attempters, mean age: 44.9±16.8)
Controls: n: 160, F:99,mean age: 42.5±8.2
Notes: no association with depression or fluoxetine response
A161T Allelic: ns
Genotypic: ns

Suicide attempts

 

 Ethnicity: Han Chinese, Taiwan

 

Hong, 2004
Cases: schizophrenia patients: F:59, M:51; mean age: 37.2±13.3
Healthy controls: F:124, M:91; mean age: 35.3±8.0
Notes: no association with schizophrenic disorders or aggression
G861C Allelic: ns
Genotypic: ns		 Suicide attempts Ethnicity: German Rujescu, 2003
Cases: suicide attempters with mood disorders: F:96, M:52; age mean: 39.5±13.3
Volunteer controls:F:179, M:148; age mean: 45.8±14.9
Notes: attempters stratified by method violence and psychiatric diagnoses
G861C Allelic: ns
Genotypic: ns		 Suicide attempts Cases: psychiatric patients: F:215, M:179; mean age: 38.9±13.6, including 132 suicide attempters; Ethnicity: Caucasian/African-American/Hispanic/Asian/Other: 280/45/55/7/7 Huang, 2003

Healthy volunteers: F:45, M:51; mean age: 40.9±15.9; Ethnicity: Caucasian/African-American/Hispanic/Asian/Other: 70/8/12/5/1
Notes: substance abuse and major depression associated with G861C
G861C Allelic:+,G, p<.01, white subsample
 Suicide attempts Ethnicity: Caucasian/Hispanic/African-American/Other: 90/27/24/4 New, 2001
Cases: personality disordered patients [F:59, M:86, mean age: 38.1±9.8], including 145 suicide attempters
Notes: no association with impulsive aggression; Bonferroni-adjusted
G861C
Genotypic: ns		 Suicide Ethnicity: Slovenian Videtic, 2006

Cases: 226 suicides (M:74.8%, mean age 49.6±17.3)
A161T Genotypic: ns 225 healthy controls
G861C Allelic: ns
Genotypic: ns 		Suicide Suicide victims: F:67, M:178,mean age: 47±19] Nonpsychiatric controls [F:120, M:128, mean age: 40±15] Ethnicity: German Stefulj, 2004
Suicide victims: F:32, M:86,mean age: 52±19] Nonpsychiatric controls [F:92, M:100, mean age: 43±12] Ethnicity: Croatian
G861C Allelic: ns
Genotypic: ns		 Suicide Ethnicity: Caucasian, mostly French Canadian Turecki, 2003

106 suicide victims
120 volunteer controls

Notes: no difference according to method or psychopathology; Bonferroni-adjusted analyses
G861C Allelic: ns
Genotypic: ns		 Suicide Ethnicity: Japanese Nishiguchi, 2001
Suicide victims: F:50, M:113; mean age: 47.9±17.6
Volunteer controls: F:50, M:113,;mean age: 44.7±14.9
G861C Allelic: ns
Genotypic: ns		 Suicide Suicide victims (F:19, M:52, mean age: 42.09±19.4); Ethnicity: White/black/ other: 51/8/12 Huang, 1999
C129T Allelic: ns
Genotypic: ns
Nonsuicidal controls (F:25, M:82, mean age: 41.6±15.6) Ethnicity: White/black/other: 55/35/17
Notes: no association with major depression, alcoholism or pathological aggression

Notes: += positive,significant; -=negative,significant; ns= nonsignificant; F=females; M=males

5-hydroxytryptamine (serotonin) receptor 1D (5HT1D)
 
Variant Association Phenotype Sample Information Author

T1350C

Allelic: ns
Genotypic: ns

Suicide

Ethnicity: Caucasian, mostly French-Canadian

 Turecki, 2003
106 suicide victims
120 volunteer controls
Notes: no difference according to suicide method or psychopathology; Bonferroni-adjusted analyses

Notes: += positive,significant; -=negative,significant; ns= nonsignificant; F=females; M=males

5-hydroxytryptamine (serotonin) receptor 1E (5HT1E)
 
Variant Association Phenotype Sample Information Author

C117T

Allelic: ns
Genotypic:ns

Suicide

Ethnicity: Caucasian, mostly French-Canadian

 Turecki, 2003
106 suicide victims
120 volunteer controls
Notes: No difference according to suicide method or psychopathology; Bonferroni-adjusted analyses

Notes: += positive,significant; -=negative,significant; ns= nonsignificant; F=females; M=males

5-hydroxytryptamine (serotonin) receptor 1F (5HT1F)
 
Variant Association Phenotype Sample Information Author

C78T

Allelic: ns
Genotypic: ns

Suicide

Ethnicity: Caucasian, mostly French-Canadian

 Turecki, 2003
106 suicide victims
120 volunteer controls
C528T Allelic: ns
Genotypic: ns 		Notes: no difference according to suicide method or psychopathology; Bonferroni-adjusted analyses
C78T Genotypic: ns Suicide Ethnicity: Slovenian Videtic,2006
Cases: 226 suicides (F:57; mean age ± SD, 49.6±17.3)

225 healthy controls

Notes: += positive,significant; -=negative,significant; ns= nonsignificant; F=females; M=males

5-hydroxytryptamine (serotonin) receptor 2A (5HT2A)
 
Variant Association Phenotype Sample Information Author

rs3125 rs6314 rs1745837 rs659734 rs1928042 rs2770296 rs582385 rs731779 rs6305 rs2070037 rs6313 rs1805055


Genotypic: ns Haplotypic :+, rs582385 - rs731779 - rs6303; p=0.05

 Suicidal ideation Etnicity: Irish Fanous, 2009
Cohort: 1,425 individuals from 270 families having more than one member with DSMIII-R schizophrenia or poor outcome schizoaffective disorders.
755 subjects with psychotic illness diagnosed by OPCRIT
T102C


Genotypic: +,CC, p=.033 relative to healthy controls

 Suicide attempts Ethnicity: Spanish Caucasian
 Vaquero-Lorenzo, 2008
Cases: 441 attempters: M:161; mean age: 38.5± 1.4 )
339 psychiatric controls:M:162,mean age: 41.9± 1.5 )
410 healthy controls: mean age: 36.2± 1.1; M:237)
C1354T (His452Tyr) Genotypic:ns Notes: no difference between attempters and psychiatric controls
T102C Allelic: ns
Genotypic: ns		 Suicide attempts Cases: 129 subjects meeting the diagnostic criteria for schizophrenia, including 42 suicide attempters (F: 19; Caucasian: 28, African: 14) and 87 nonattempters (F: 31, Caucasian: 56, African: 31)

Correa, 2007

Healthy controls (n: 85)
Notes: no association with suicide attempt characteristics

rs6311 rs6313 rs643627 rs1923882 rs7322347

Allelic: ns

Genotypic: ns

Haplotypic: ns

 Suicide attempts

Ethnicity: Han Chinese

 Zhang, 2007

Cases: 297 (F:126; mean age 46.10 ± 12.76 ) suicide attempters
Controls: 329 (F:112; mean age 43.22 ± 12.77) psychiatric patients without attempted suicide

His452Tyr

C102T

 

 Allelic: ns Suicidal behaviour severity Cases: 336 (F:62%) bipolar patients from 305 nuclear families (mean age: 35.36± 10.37 SD), including 267 patients with suicide ideas/ attempts De Luca, 2007
Notes: suicidality assessed quantitatively and coded as follows: 0 = absence of suicide/death thoughts, 1 = thoughts of death, 2 = suicide ideation, 3 = suicide plan, 4 = suicide attempt; marginal association between TH and severe suicidal behaviour
rs63627 Allelic: ns

Suicide attempts

 Ethnicity: German

 

Giegling, 2006
rs594242 Allelic: ns Suicide attempts Cases: 203 suicide attempters (F:135; 133 nonviolent; 120 impulsive): age mean: 40.0±13.0
rs6311 Allelic:+, C, p=.009 Nonviolent suicide attempts Controls: 363 healthy volunteers (F:201): age mean: 46±15
Allelic:+, C, p=.01 Impulsive suicide attempts
  Haplotypic: multiple nonviolent or impulsive suicide attempts Notes: rs6311's CC genotypes showed more anger and aggression-related traits
C102T Allelic: ns
Genotypic: ns		 Suicide attempts Ethnicity: Caucasian, European Khait, 2005
Cases: attempters with mood disorders [n:56 (F:42), age mean: 37.42±12.75] and nonattempters with mood disorders [n: 100 (F:58), age mean: 40.92±15.5)]
Controls: n: 63 healthy volunteers, age mean: 40±17
C102T Allelic: ns
 Suicide attempts Ethnicity: Ashkenazi Jewish Zalsman, 2005
Cases: families of recent teen attempters [n: 30 (F:16), mean age: 15.7±1.4] including 50 biological parents
Notes: no association with clinical traits
G1438A Allelic: ns
Genotypic: ns		 Suicide attempts Ethnicity: West European Etain, 2004
Cases: bipolar patients [F:198, M:158, mean age: 43±13.7]
His452Tyr Allelic: ns
Genotypic: ns		 Healthy controls [F:116, M:92, mean age: 43±8.0]
  Haplotypic: ns Notes: no difference in relation to bipolar diagnosis, violent suicide attempts or family history of suicide attempts: Bonferroni-adjusted
T102C Allelic: ns
Genotypic: ns		 Suicide attempts Ethnicity: European Oswald, 2003

Cases: 142 patients with unipolar affective disorder (UPD), including 33 suicide attempters

Matched controls: 142
Notes: no association with UPD
G1438A Allelic: ns
Genotypic: -, AA, p=.008, bipolar I		 Suicide attempts Ethnicity: Caucasian Bonnier, 2002
Cases: patients with unipolar (n:127) or bipolar (n:65) disorder [F:63%, mean age: 45.3±14.4]
Nonpsychiatric controls [F:54.2%, mean age: 73.6±8.3]
T102C Allelic: ns
Genotypic: ns		 Suicide attempts Ethnicity: Brazilian Correa, 2002
Cases: patients with recurrent major depression (n:78) or schizophrenia (n:95) including 66 suicide attempters
Healthy controls: F:27, M:25
Notes: no difference in severity of attempts
T102C Allelic: ns
Genotypic: ns		 Suicide attempts Ethnicity: Chinese Tan, 2002
Cases: schizophrenia patients with (n:47) or without suicide attempts (n:239), and with suicidal ideation (n:62)
Nonpsychiatric controls (n:94)
Notes: no association with schizophrenia
T102C Allelic: ns
Genotypic: ns		 Suicide attempts Ethnicity: Spanish Arias, 2001
Cases: patients with major depression (n:159, mean age: 54.86±16.21, F: 108, 21% attempted suicide)
Healthy controls (N:164, F: 81, mean age: 41.4±10.35)
Notes: Bonferroni-adjusted; C allele carriers overrepresented in patients with seasonal depressive disorder
T102C Allelic:+,C, p=.04
Genotypic: +, CC/CT, OR: 5.5 95% CI 1.18-35.20		 Suicide attempts Ethnicity: Spanish Arias, 2001
Cases: patients with major depression (n:159, mean age: 54.86±16.21, 108 suicidal ideators and 33 suicide attempters, F: 108)
Healthy controls (N:162 (F:81), mean age: 41.4±10.35)
Notes: no association with major; C carriers overrepresented among suicidal ideators without suicide attempt histories
C1/C2 Allelic: ns
Genotypic: ns		 Suicide attempts Ethnicity: European Caucasian, mostly Swedish Geijer, 2000
Cases: suicide attempters:F: 108, M: 57, mean age: 41 ±17
99 nonpsychiatric controls ( F:95, mean age 38±6)
Notes: no association when stratified by diagnosis or ethnicity
G1438A Allelic: ns
Genotypic: ns		 Suicide attempts Ethnicity: Japanese Ohara, 1998
Cases: mood-disordered patients [F:44, M:51, mean age: 44.9±16.2, including 14 suicide attempters]
Healthy controls [F:59, M:47, mean age: 36.4±15.2]
Notes: no association with mood disorders
T102C

Allelic:+,C, p=.005
Genotypic: +,CC, OR: 3.1 95% CI 1.7-5.8

Suicidal ideas Ethnicity: Caucasian Du, 2000
Cases: major depression patients, including 78 suicidal ideators: F:72, M:48, mean age: 39.32±9.53
Healthy controls: F:70, M:61, mean age: 35.95±11.34
Notes: C allele associated with major depression
T102C Allelic: ns
Genotypic: ns

Suicide attempts

Suicidal ideas

 Ethnicity: Caucasian, South Germany Preuss, 2000
Cases: patients with alcohol-dependence: F:31, M: 119, mean age: 41.4±9.3, including 45 suicide attempters
General population controls: F:61, M:56, mean age: 46.8±12
Notes: not associated with depression
T102C Allelic: ns
Genotypic: ns

Suicidal ideas

Suicide

Ethnicity: Caucasian, South Germany Bondy, 2000
Cases: 1. suicides: F:40, M:91, mean age:45.6± 16.4. 2. patients with major depression with or without suicidal thoughts: F:56, M:28, mean age: 52.8±11.9
Healthy controls: F:65, M:60, mean age: 47.8±12.4
Notes: no differences in the method of or age of victim; no association with major depression or suicide defined as a syndrome
C1420T Genotypic: ns Suicide Ethnicity: Slovenian Videtic, 2006
Cases: 226 suicides (F:57, mean age ± SD, 49.6±17.3)

225 healthy controls
G1438A Allelic: ns
Genotypic: ns		 Suicide Ethnicity: Japanese Ono, 2001
Cases: suicides (M:106, mean age: 49.1±17.1; F:45,mean age: 45.8±19.2)
General population controls (M:108, mean age: 44.9±15.3; F:55,mean age: 48.4±18.8)
T102C Allelic: ns
Genotypic: ns		 Suicide Ethnicity: Largely Caucasian, South Australia Crawford, 2000
Cases: 68 suicides
Controls: 95
T102C Allelic: ns
Genotypic: ns		 Suicide Geographic origin: Budapest Faludi, 2000
Cases: depressed suicides: n:32
Controls who died of causes unrelated to the CNS: n:57
His452Tyr Allelic: ns
Genotypic: ns
T102CHis452Tyr Allelic: ns
Genotypic: ns

Suicide

 

 Location: Budapest Du, 1999
Cases: 24 depressed suicide completers ( mean age: 50.7 ± 30.2)
Controls who died from nonsuicide-related causes and with no evidence of psychiatric illness were matched for age, sex, and postmortem delay (n:31, mean age: 45.5 ± 2.8)
Notes: HTR2A genotypes not associated with frontal cortex density
T102C Allelic: ns
 Suicide Ethnicity: French Canadian Turecki, 1999
Cases: 56 suicides, mean age: 36.09±10.75
126 comparison subjects dying from cardivascular diseases, mean age: 33.54±9.95
G1438A Allelic: ns Notes: HTR2A binding greater in the prefrontal cortex of suicides and influenced by its DNA variation
  Haplotypic: ns
T102C Allelic: ns
Genotypic: ns		 Suicidality Ethnicity: mixed Ertugrul, 2004
Cases: schizophrenia patients [F:20, M:51, mean age:32.8± 8.7] or schizoaffective disorder (n:6), currently suicidal patients [F:13, M:33, mean age:34.1± 8.9]
Notes: suicidality defined on a continuum

Notes: += positive,significant; -=negative,significant; ns= nonsignificant; F=females; M=males; T102C=rs6313, His452Tyr=rs6314, C1019G=rs6295

5-hydroxytryptamine (serotonin) receptor 2C (5HT2C)
 
Variant Association Phenotype Sample Information Author

-G995A

 

Cys23Ser

Genotypic: ns Allelic :ns

Genotypic:+;GG; F; CI 95%=0.175-0.728; OR=0.357;

Allelic:+;G;F; χ2=5.14; p=0.028;

Allelic:+; G;F+M;χ2=7.25; p=0.005;CI 95%=0.370-0.859; OR=0.564;

 Suicide Ethnicity: Slovenian Videtič, 2009
Cases: 334 suicides ; F=25.45%; M=74.45%mean age: 49.06 ± 17.8
Controls: 211; F=35.55%; M=64.45%; mean age: 47,06 ± 19.2
5HT2C STR rs6318

Allelic: ns

Haplotypic: ns

 Suicide attemps in bipolar disorder 312 nuclear families with at least one offspring affected by BD. De Luca, 2008
350 affected with BD (131 males and 219 females) mean age: 20 ± 7.58
Eighty-six patients attempted suicide

rs1023574 rs9698290 rs6318

 

Allelic: ns

Genotypic: ns

Haplotypic: ns

 Suicide attempts

Ethnicity: Han Chinese

 Zhang, 2007

Cases: 297 suicide attempters (F: 126; mean age 46.10 ± 12.76 )

Controls: 329 (F:112; mean age 43.22 ± 12.77) psychiatric patients who had never attempted suicide

Cys23Ser

 Allelic: ns
Genotypic:ns 		Suicide Cases: suicides: F:81, M:203;mean age ± SD, 47±18; Nonpsychiatric controls: F:146, M:151; mean age ± SD, 41±15 Ethnicity: German Stefulj, 2004
Cases: suicides: F:32, M:86;mean age ± SD, 52±20; Nonpsychiatric controls: F:112, M:163; mean age ± SD, 43±12 Ethnicity: Slavic, Croatia

G995A

Allelic: ns
Genotypic:ns

Suicide

Ethnicity: Caucasian, mostly French-Canadian

 Turecki, 2003
106 suicide victims
120 volunteer controls
Notes: no difference according to suicide method or psychopathology; Bonferroni-adjusted analyses

rs547536 rs2192372
rs6318 rs2428707 rs4272555
rs1801412

Genotypic: ns Haplotypic: ns

Suicide attempts

Suicide

Ethnicity: German,Italian

Serretti, 2007

Cases: 1a. German suicide attempters: n:167(F :109), mean age: 39.89±13.89, 101 impulsive, 60 violent 1b. Suicides: n:92 (F:39)
2a.Italian mood disordered patients [n: 463 subjects (F:308; 49.50±13.52), including  152 suicide attempters; mean age 50.00±13.02 and 311 non-suicide patients, mean age 49.25±13.77]
Controls: 3a. German: 312 (F:174;  mean age 45.01±14.92 years (range 19–79); 3b. Italian: 13 1
Italian healthy volunteers (F:47, M:84, aged 48.01±13.82)

Notes: only rs6318 analyzed in the Italian sample

Notes: += positive,significant; -=negative,significant; ns= nonsignificant; F=females; M=malesCys23Ser=rs6318.

5-hydroxytryptamine (serotonin) receptor 5A (5HT5A)
 
Variant Association Phenotype Sample Information Author

G19C

Allelic: ns
Genotypic: ns

Suicide

Ethnicity: Caucasian, mostly French-Canadian

 Turecki, 2003
106 suicide victims
120 volunteer controls
Notes: no difference according to suicide method or psychopathology; Bonferroni-adjusted analyses

Notes: += positive,significant; -=negative,significant; ns= nonsignificant; F=females; M=males

5-hydroxytryptamine (serotonin) receptor 6 (5HT6)
 
Variant Association Phenotype Sample Information Author
267C/T

Genotypic: M+F; ns χ2 = 5.374,
df=2, p = 0.068

Genotypic: M ; χ2 = 6.988, df = 2, p = 0.030

 

Suicide completers Origin: Portuguese Azenha, 2009
Controls: 189 persons without any history of neuropsychiatric disorders F=47, mean age: 60.5±16.9; M=142, mean age: 55.4±18.1.
Suicide: 179 persons, F=50 mean age: 51.5±19.7; M= 129, mean age 53.4±17.7

(GCC)2/3

C267T

Allelic: ns
Genotypic: ns Haplotypic:ns

 Suicide

Ethnicity: Japanese

 Okamura, 2005
Cases: 163 suicide victims (F: 50, mean age ± SD, 47.6±17.9)
Nonpsychiatric controls: 166 (F:52; mean age ± SD, 45.7±16.4)

C267T

 

 

 Allelic: ns
Genotypic:ns 		Suicide

Ethnicity: Caucasian, mostly French-Canadian

 Turecki, 2003
106 suicide victims
120 volunteer controls
Notes: no difference according to suicide method or psychopathology; Bonferroni-adjusted analyses

Notes: += positive,significant; -=negative,significant; ns= nonsignificant; F=females; M=males